Why are nat­u­ral com­pounds bet­ter than syn­thet­ic chem­i­cals to treat dis­eases? We have inten­sive­ly ana­lyzed all those known com­pounds in the nat­u­ral prod­ucts, and found that the­se com­pounds have high­er sim­i­lar­i­ty, espe­cial­ly struc­tural sim­i­lar­i­ty, to human metabo­lites.